Projects

Project division A “topography and induction of the immune response in the gut”:

Subproject A1 - Project leaders: Radbruch, Dr. Scheffold.

Analysis of the presentation of orally applied antigens and the specific T cell reaction:  tolerance versus immunity .

Subproject A4 - Project leaders: Prof. Dr. Duchmann, Prof. Dr. Sieper, Thiel. Other team members: Scheer, Steinbrich-Zöllner

Identification of T cell epitopes relevant for inflammatory bowel diseases and their rheumatic manifestations.

Subproject A5 - Project leaders: Prof. Dr. Blankenstein, Dr. Willimsky.

Analysis of the spontaneous and induced immune response against tumors of the gastrointestinal tract .

Subproject A7 - Project leaders: Prof. Dr. Blaut, Prof. Dr. Göbel, Prof. Dr. Schumann. Other team members: Bereswill, Fischer, Woellner

Analysis of the intestinal flora and its interaction with the mocosa of gnotobiotic mice and relation to the TLR/NOD gene family and LPS binding proteine including therapeutic intervention strategies .

Subproject A8 - Project leader: Prof. Dr.Hamann, Dr. Klugewitz. Other team members: Kruse,  Neumann,  Rudolph

The liver as a part of the mucosal immune system: activation and antigen-dependent recruitment of CD4+ T cell after oral antigen uptake.

Subproject A10 - Project leader: Dr. Schott. Other team members: Eickmeier, Seidel

Relevance of the enterohepatic circuit of T lymphocytes for the development of extraintestinal manifestations of chronic inflammatory bowel disease in the liver.

Subproject A12 - Project leader: Dr. Siegmund. Other team members: Dr. Batra, Fedke,  Stroh

Mesenteric adipose tissue and the regulatory function in intestinal inflammation .

Subproject A13 - Project leader: Prof. Dr. Nedospasow. Other team members: Kruglov, Lemansky

Role of tumor necrosis factor and lymphotoxin produced by T cells and by lymphoid tissue inducer cells in the organization of lymphoid tissues critical for mucosal immunity and mucosal inflammation .

Subproject A14 - Project leaders: Prof. Dr. Duchmann, Dr. Ullrich. Other team members: Grabowski, Dr. Hostmann,  Münchow

Characterization of human peripheral and intestinal T cell responses after mucosal antigen exposition: Induction of tolerance vs. immunity .

Project division B “regulation and modulation of the intestinal immunity”:

Subproject B1 - Project leaders: Prof. Dr. Hamann. Other team members: Szilagyi

Impact of the mucosal environment for the induction of specific homing and functional differentiation of T cells.

Subproject B2 - Project leaders: Dr. Höpken, Dr. Dr. Lipp. Other team members: Schradi, Schwede, Wichner

Regulation of lymphocyte effector / memory functions in the mucosal immune response.

Subproject B6 - Project leader: Dr. Heimesaat. Other team members: Bereswill, Lohmann, Munoz-Roldan

Mechanism of induction and effector function in T-cell-mediated ileitis following oral infection with Toxoplasma gondii.

Subproject B7 - Project leader: Dr. Steinhoff. Other team members: Krienke, Lawrenz, Seipel

Analysis of proteasome mediated inflammation in patients with inflammatory bowel disease.

Subproject B9 - Project leaders: Dr. Moos, Prof. Dr. Schneider. Other team members: Allers, Geelhaar, Schinnerling, Seipel

Investigation of interactions of T cells and antigen-presenting cells.

Subproject B10 - Project leaders: Prof. Dr. Radbruch, Dr. Thiel. Other team members: Chang, Möwes, Sommer

The role of permanently activated, proinflammatory T cells in chronic mucosal inflammation.

Subproject B11 - Project leaders: Dr. Maul, Dr. Rieger, Prof. Dr. Uharek. Other team members: Flöckner, Großmann, Klopfleisch

Cellular approaches for the treatment of intestinal Graft-versus-Host disease and inflammatory bowel disease.

Subproject B12 - Project leaders: Prof. Dr. Aebischer, Dr. Igantius, Prof. Dr. Meyer. Other team members: Fehlings, Schneider

Modulation of the T cell dependent immune defence against Helicobacter pylori under the influence of cholesterol.

Subproject Z1 - Project leaders: Prof. Dr. Loddenkemper, Prof. Dr. Stein, Prof. Dr. Zeitz. Other team members: Dr. Erben, May, Dr. Schulzke, Dr. Schumann, Spieckermann

Development of systematic morphological methods for the evaluation of mucosal inflammations and the in-situdetection of defined cell populations.