Subproject B01

Induction of specific homing receptors and of regulatory properties in mucosal T cells

Prof. Dr. rer. nat. Alf Hamann

hamann-alf-portrait-27072011 01

Steering Committee and Leader of the Subproject B01

Deutsches Rheuma-Forschungszentrum Berlin - Experimental Rheumatology

Postal address:

Charitéplatz 1

10117 Berlin

t: +49 30 2846 0655

f: +49 30 2846 0656

T cells of the gastrointestinal tract are characterized by mucosa-specific homing as well as responses biased towards tolerance. The project investigates the cellular and molecular regulation of the mucosa-specific homing- and chemokine receptors α4β7 and CCR9 by the gut environment. In addition, we study the crosstalk between microbiota of the gut with T cells, notable the question whether metabolites and components of commensal bacteria are able to induce regulatory T cells. Insights into these tolerance mechanisms might reveal novel strategies for the therapy of inflammatory diseases.

 

 

Head of office

Birgit Röders

Birgit Roeders

Charité – Universitätsmedizin Berlin

CBF: Campus Benjamin Franklin

Charité Center Internal Medicine with Gastroenterology and Nephrology CC 13

Postal address:

Hindenburgdamm 30

12203 Berlin

t: +49 30 8445 2820

f: +49 30 8445 2820