Immune response to Intracellular Pathogens and Toxoplasma gondii induced intestinal inflammation model

Refentin: Melba Munos

Naive T cells differentiate into T cells subset populations in the presence of different factors including pathogen derived signals. Host adaptive immunity is a crucial arm of the immune response that provides protection against microorganisms. After infection clearance, the immune response needs be turned off. An uncontrolled immune response can cause chronic inflammation and autoimmunity.
We study inflammatory immune responses in the intestine using a murine model of Toxoplasma gondii. The undestanding of the development of immunopathology will help us to design new therapies to control chronic inflammatory diseases.