Infection Models

Referent: Dr. Markus Heimesaat

In vivo models for studying the interplay of the innate immune system of vertebrates and the gut pathogen Campylobacter (C.) jejuni are scarce. We will discuss the limitations of developing an appropriate mouse model and possible strategies to overcome these pitfalls. Furthermore, we will elucidate interactions of the commensal gut flora and the innate immune system of the host with the pathogen C. jejuni as well as resulting mucosal inflammation. Finally, we will speculate about potential clinical implications based upon the data derived from the animal model.